TPM3

Across TCGA cell cohorts, TPM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,156 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TPM3-associated GO terms across cancer lineages are Regulation of protein sumoylation, Response to dehydroepiandrosterone, and Mitotic spindle elongation. Each is linked with TPM3 in more than 15 cancer types. Because this analysis shows association rather than direction, both TPM3-to-partner and partner-to-TPM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein sumoylation grouped by TPM3-low versus TPM3-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPM3→partner) and Y-score (partner→TPM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of protein sumoylation →	+0.118	+0.965	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Response to dehydroepiandrosterone →	+0.213	+1.258	<.001	<.001	3	14
BONE	Mitotic spindle elongation →	+0.245	+0.751	.006	<.001	2	14
BONE	Mitotic spindle midzone assembly →	+0.245	+0.751	.006	<.001	2	14
OVARY	Interleukin-34-mediated signaling pathway →	+0.186	+1.010	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	RISC complex assembly →	+0.068	+0.788	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,156 associations by consensus.

Regulation of protein sumoylation by TPM3 expression — SKIN

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