Across TCGA patient cohorts, TPM2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPM2-associated genes across cancer lineages are Ku80, Cyclin-B1, and EGFR_pY1068. Each is linked with TPM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPM2-to-partner and partner-to-TPM2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPM2→partner) and Y-score (partner→TPM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.207	+1.598	.025	.022	3	2
UCEC	Cyclin-B1 →	+0.612	+2.459	.005	.018	3	2
UCEC	EGFR_pY1068 →	-0.270	-2.000	.006	.010	3	1
UCEC	PDCD4 →	-0.560	-2.584	.002	.010	3	1
UCEC	Rab11 →	-0.129	-2.000	.023	.010	3	1
UCEC	Rab25 →	-0.450	-3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

TPM2 survival (RNA) · tumor vs normal (RNA) · all TPM2 data types