Across TCGA cell cohorts, TPM2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPM2-associated genes across cancer lineages are MAGEB4, PPDPFL, and FAM205A. Each is linked with TPM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPM2-to-partner and partner-to-TPM2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPM2→partner) and Y-score (partner→TPM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.019	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	PPDPFL →	+0.048	+4.217	<.001	.001	3	1
LARGE_INTESTINE	FAM205A →	+0.025	+4.614	<.001	.002	3	1
LARGE_INTESTINE	OR5M11 →	+0.132	+4.095	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

TPM2 survival (RNA) · tumor vs normal (RNA) · all TPM2 data types