TPM1

Across TCGA patient cohorts, TPM1 mutation is significantly associated with the RNA expression of many other genes, with 1,323 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPM1-associated genes across cancer lineages are RNA5SP506, PUDPP1, and ADNP2. Each is linked with TPM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPM1-to-partner and partner-to-TPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP506 grouped by TPM1-low versus TPM1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPM1→partner) and Y-score (partner→TPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNA5SP506 →	+0.346	+6.149	<.001	.002	3	2
LIHC	PUDPP1 →	+0.691	+5.758	<.001	.003	3	2
UCEC	ADNP2 →	+0.501	+2.155	.004	.009	3	2
UCEC	MED31 →	+0.379	+2.534	.003	<.001	3	2
UCEC	FOXRED1 →	+0.360	+2.628	.003	.005	3	2
UCEC	PDHX →	+0.398	+2.624	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,323 associations by consensus.

RNA5SP506 by TPM1 expression — LIHC

Explore this box plot interactively →