TPM1

Across TCGA patient cohorts, TPM1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPM1-associated genes across cancer lineages are FASN, Caspase-7-cleavedD198, and EGFR. Each is linked with TPM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPM1-to-partner and partner-to-TPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by TPM1-low versus TPM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPM1→partner) and Y-score (partner→TPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.358	+3.000	.024	.036	3	2
UCEC	Caspase-7-cleavedD198 →	+0.729	+2.720	.002	.003	3	2
UCEC	EGFR →	-0.143	-1.906	.026	.016	3	1
UCEC	eIF4E →	+0.221	+2.000	.009	.030	3	1
UCEC	ERCC1 →	-0.140	-2.000	.043	.030	3	1
UCEC	Heregulin →	-0.138	-3.156	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

FASN by TPM1 expression — UCEC

Explore this box plot interactively →