Across TCGA pan-cancer cohorts, TPK1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TPK1 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TPK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TPK1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

KIRP, HNSC, and LUAD are the cancer types where TPK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.132	0.904	<.001	36	view →
HNSC	OS	Median	III,IV	0.156	0.673	.024	12	view →
LUAD	OS	Median	III,IV	0.158	0.663	.008	12	view →
UCEC	DFS	Median	All	0.948	0.623	.049	2	view →
SKCM	OS	Median	III,IV	1.000	0.800	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TPK1 tumor-vs-normal RNA expression · all TPK1 data types