Across TCGA pan-cancer cohorts, TPK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TPK1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TPK1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TPK1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where TPK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.666	0.408	<.001	82	view →
HNSC	OS	Median	II,III,IV	0.953	1.000	.019	11	view →
CCRCC	OS	Tertile	All	0.964	0.618	.033	5	view →
LSCC	DFS	Quartile	II,III,IV	0.795	1.000	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TPK1 tumor-vs-normal RNA expression · all TPK1 data types