Across TCGA patient cohorts, TPK1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPK1-associated genes across cancer lineages are Di-Ras3, FASN, and INPP4B. Each is linked with TPK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPK1-to-partner and partner-to-TPK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPK1→partner) and Y-score (partner→TPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.145	-2.986	.036	.035	3	2
UCEC	FASN →	+0.524	+3.000	.004	.036	2	2
UCEC	INPP4B →	-0.314	-3.169	.037	.018	3	1
UCEC	ACVRL1 →	-0.134	-3.156	.034	.018	3	1
UCEC	Ku80 →	+0.328	+2.598	.002	.006	3	1
UCEC	MEK1 →	+0.454	+2.321	.007	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

TPK1 survival (RNA) · tumor vs normal (RNA) · all TPK1 data types