Across TCGA cell cohorts, TPK1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPK1-associated genes across cancer lineages are PPP1R17, HSFY2, and ACSM6. Each is linked with TPK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPK1-to-partner and partner-to-TPK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPK1→partner) and Y-score (partner→TPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP1R17 →	+0.045	+4.882	.004	<.001	3	1
LARGE_INTESTINE	HSFY2 →	+0.015	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	ACSM6 →	+0.026	+4.169	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
SKIN	OR11G2 →	+0.012	+3.345	<.001	.007	3	1
SKIN	DYTN →	+0.071	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

TPK1 survival (RNA) · tumor vs normal (RNA) · all TPK1 data types