TPI1

Across TCGA pan-cancer cohorts, TPI1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TPI1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TPI1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TPI1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

LUAD, UCEC, and CCRCC are the cancer types where TPI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.572	0.867	.002	33	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.338	.004	18	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	10	view →
PDAC	DFS	Tertile	II,III,IV	0.633	0.815	.014	8	view →
LSCC	DFS	Quartile	All	0.999	0.851	.022	6	view →
GBM	DFS	Median	All	0.626	0.806	.017	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TPI1–LUAD (OS)

Open the LUAD breakdown →