TPI1

Across TCGA patient cohorts, TPI1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPI1-associated genes across cancer lineages are eEF2, Ku80, and p62 Lck ligand. Each is linked with TPI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPI1-to-partner and partner-to-TPI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TPI1-low versus TPI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPI1→partner) and Y-score (partner→TPI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.489	+3.000	.006	.036	3	1
UCEC	Ku80 →	+0.304	+2.335	.010	.020	3	1
UCEC	p62 Lck ligand →	+0.744	+3.459	<.001	.005	3	1
UCEC	Paxillin →	+0.337	+3.459	.009	.005	3	1
UCEC	PEA-15_pS116 →	+0.500	+3.169	.004	.019	3	1
UCEC	Annexin-1 →	+0.612	+2.321	.020	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eEF2 by TPI1 expression — UCEC

Explore this box plot interactively →