TPI1

Across TCGA cell cohorts, TPI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,891 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible TPI1-associated GO terms across cancer lineages are Spindle elongation, DNA replication initiation, and Mitotic spindle elongation. Each is linked with TPI1 in more than 13 cancer types. Because this analysis shows association rather than direction, both TPI1-to-partner and partner-to-TPI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by TPI1-low versus TPI1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPI1→partner) and Y-score (partner→TPI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Spindle elongation →	+0.283	+1.289	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.118	+0.721	<.001	<.001	3	14
PANCREAS	Mitotic spindle elongation →	+0.185	+0.784	<.001	<.001	3	13
PANCREAS	Mitotic spindle midzone assembly →	+0.185	+0.784	<.001	<.001	3	13
LIVER	Ribonucleoside diphosphate metabolic process →	+0.074	+0.753	.001	.004	3	12
KIDNEY	Carbohydrate biosynthetic process →	+0.086	+0.975	.002	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,891 associations by consensus.

Spindle elongation by TPI1 expression — URINARY_TRACT

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