TPH2

Across TCGA patient cohorts, TPH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,018 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TPH2-associated GO terms across cancer lineages are Protein stabilization, Regulation of protein serine/threonine kinase activity, and Golgi vesicle transport. Each is linked with TPH2 in more than 17 cancer types. Because this analysis shows association rather than direction, both TPH2-to-partner and partner-to-TPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein stabilization grouped by TPH2-low versus TPH2-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPH2→partner) and Y-score (partner→TPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Protein stabilization →	+0.101	+0.144	<.001	.001	2	18
STAD	Regulation of protein serine/threonine kinase activity →	+0.060	+0.084	<.001	<.001	3	17
ESCA	Golgi vesicle transport →	+0.096	+0.118	<.001	.002	3	16
ESCA	Organelle disassembly →	+0.095	+0.108	<.001	.009	2	17
STAD	Vesicle budding from membrane →	+0.073	+0.082	<.001	<.001	3	16
STAD	Response to UV →	+0.071	+0.088	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,018 associations by consensus.

Protein stabilization by TPH2 expression — ESCA

Explore this box plot interactively →