TPH2

Across TCGA patient cohorts, TPH2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPH2-associated genes across cancer lineages are Caspase-7-cleavedD198, JNK2, and AMPK_alpha. Each is linked with TPH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TPH2-to-partner and partner-to-TPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TPH2-low versus TPH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPH2→partner) and Y-score (partner→TPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.765	+2.906	.002	.001	3	3
LUSC	JNK2 →	+0.262	+1.764	<.001	.048	3	2
LUSC	AMPK_alpha →	+0.176	+1.874	.002	.046	3	2
LUSC	STAT5a →	+0.412	+1.594	.029	.021	3	2
UCEC	Di-Ras3 →	-0.167	-3.308	.008	.009	3	2
UCEC	STAT3_pY705 →	-0.382	-3.690	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by TPH2 expression — UCEC

Explore this box plot interactively →