TPH2

Across TCGA cell cohorts, TPH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 857 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible TPH2-associated GO terms across cancer lineages are Nucleic acid catabolic process, Regulation of protein localization to nucleus, and Negative regulation of mRNA splicing, via spliceosome. Each is linked with TPH2 in more than 4 cancer types. Because this analysis shows association rather than direction, both TPH2-to-partner and partner-to-TPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleic acid catabolic process grouped by TPH2-low versus TPH2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPH2→partner) and Y-score (partner→TPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nucleic acid catabolic process →	+0.042	+0.030	.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to nucleus →	+0.053	+0.036	.004	.002	3	5
OESOPHAGUS	Negative regulation of mRNA splicing, via spliceosome →	+0.093	+0.052	.004	.003	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of plasma cell differentiation →	+0.070	+0.027	.009	.004	3	4
BONE	Lipoprotein transport →	+0.116	+0.329	.003	.008	3	4
BONE	Lipoprotein localization →	+0.114	+0.329	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 857 associations by consensus.

Nucleic acid catabolic process by TPH2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →