TPH2

Across TCGA cell cohorts, TPH2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPH2-associated genes across cancer lineages are CHRNA2, SULT6B1, and CMKLR1. Each is linked with TPH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPH2-to-partner and partner-to-TPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNA2 grouped by TPH2-low versus TPH2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPH2→partner) and Y-score (partner→TPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHRNA2 →	+0.075	+3.938	<.001	<.001	3	1
LARGE_INTESTINE	SULT6B1 →	+0.025	+3.240	<.001	.004	3	1
LARGE_INTESTINE	CMKLR1 →	+0.111	+3.830	.006	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.210	+3.425	.003	<.001	3	1
LARGE_INTESTINE	C16orf96 →	+0.458	+3.652	.006	.001	3	1
LARGE_INTESTINE	DAZ4 →	+0.123	+3.240	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CHRNA2 by TPH2 expression — LARGE_INTESTINE

Explore this box plot interactively →