TPH1

Across TCGA patient cohorts, TPH1 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,261 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TPH1-associated proteins across cancer lineages are MNDA, NCF2, and STXBP1. Each is linked with TPH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TPH1-to-partner and partner-to-TPH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPH1 versus MNDA in LSCC, with a Pearson correlation of -0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TPH1→partner) and Y-score (partner→TPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MNDA →	-0.687	-0.496	<.001	<.001	3	4
GBM	NCF2 →	-0.515	-0.412	<.001	.001	3	4
UCEC	STXBP1 →	+0.637	+1.970	<.001	<.001	3	3
PDAC	TCIRG1 →	-0.489	-0.457	<.001	<.001	3	3
LSCC	TOP2B_S1413 →	+0.635	+0.318	<.001	<.001	3	3
LSCC	UNC13D →	-0.395	-0.347	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,261 associations by consensus.

TPH1 vs MNDA — LSCC

Explore this scatter interactively →