TPH1

Across TCGA patient cohorts, TPH1 mutation is significantly associated with the RNA expression of many other genes, with 2,841 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPH1-associated genes across cancer lineages are SEC13, PANK4, and C16orf86. Each is linked with TPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPH1-to-partner and partner-to-TPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by TPH1-low versus TPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPH1→partner) and Y-score (partner→TPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.353	+2.939	<.001	<.001	3	2
UCEC	PANK4 →	+0.347	+2.375	.001	.002	3	2
SKCM	C16orf86 →	+0.789	+3.484	<.001	.002	3	2
UCEC	IQCC →	+0.455	+2.523	<.001	<.001	3	2
UCEC	UBE2J2 →	+0.257	+2.959	.006	<.001	3	2
UCEC	C19orf47 →	+0.326	+1.748	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,841 associations by consensus.

SEC13 by TPH1 expression — UCEC

Explore this box plot interactively →