TPH1

Across TCGA patient cohorts, TPH1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPH1-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and FoxM1. Each is linked with TPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPH1-to-partner and partner-to-TPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TPH1-low versus TPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPH1→partner) and Y-score (partner→TPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.208	+3.335	.007	.005	3	1
UCEC	A-Raf_pS299 →	-0.111	-1.700	.011	.042	3	1
UCEC	FoxM1 →	+0.198	+1.847	.037	.008	3	1
UCEC	GATA6 →	-0.124	-2.985	.033	.034	3	1
UCEC	INPP4B →	-0.278	-2.584	.019	.010	3	1
UCEC	MEK1 →	+0.394	+2.321	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eIF4E by TPH1 expression — UCEC

Explore this box plot interactively →