TPH1

Across TCGA cell cohorts, TPH1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TPH1-associated genes across cancer lineages are REG3G, TIFAB, and MT1B. Each is linked with TPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPH1-to-partner and partner-to-TPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3G grouped by TPH1-low versus TPH1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPH1→partner) and Y-score (partner→TPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	REG3G →	+0.051	+4.867	<.001	.009	3	2
LARGE_INTESTINE	TIFAB →	+0.006	+4.977	<.001	.007	3	1
BREAST	MT1B →	+0.103	+5.169	<.001	.005	3	1
BREAST	TCP11X1 →	+0.013	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

REG3G by TPH1 expression — BLOOD_Lymphoma

Explore this box plot interactively →