TPGS1

Across TCGA patient cohorts, TPGS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,027 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TPGS1-associated GO terms across cancer lineages are tRNA thio-modification, Negative regulation of protein localization to chromatin, and Peptidyl-glutamic acid modification. Each is linked with TPGS1 in more than 25 cancer types. Because this analysis shows association rather than direction, both TPGS1-to-partner and partner-to-TPGS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA thio-modification grouped by TPGS1-low versus TPGS1-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPGS1→partner) and Y-score (partner→TPGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	tRNA thio-modification →	+0.115	+0.934	.005	<.001	1	26
SCLC	Negative regulation of protein localization to chromatin →	+0.168	+0.912	<.001	<.001	3	23
SCLC	Peptidyl-glutamic acid modification →	+0.065	+0.481	.002	.004	3	23
ACC	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence →	+0.066	+1.188	<.001	<.001	3	22
ESCA	Protein polyglutamylation →	+0.052	+0.374	<.001	<.001	3	22
ACC	Tail-anchored membrane protein insertion into ER membrane →	+0.049	+1.041	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,027 associations by consensus.

tRNA thio-modification by TPGS1 expression — SCLC

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