TPGS1

Across TCGA cell cohorts, TPGS1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TPGS1-associated genes across cancer lineages are GAGE12J, TBL1Y, and FUT5. Each is linked with TPGS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPGS1-to-partner and partner-to-TPGS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12J grouped by TPGS1-low versus TPGS1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPGS1→partner) and Y-score (partner→TPGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
LARGE_INTESTINE	FUT5 →	+0.023	+3.920	.001	.005	3	1
LARGE_INTESTINE	CACNG3 →	+0.005	+4.217	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR6M1 →	+0.058	+5.228	<.001	.005	3	1
BLOOD_Leukemia	PPP1R2C →	+0.307	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GAGE12J by TPGS1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →