TPD52L3

Across TCGA patient cohorts, TPD52L3 mutation is significantly associated with the RNA expression of many other genes, with 1,135 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPD52L3-associated genes across cancer lineages are TMEM161B, PTGES, and WDHD1. Each is linked with TPD52L3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TPD52L3-to-partner and partner-to-TPD52L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM161B grouped by TPD52L3-low versus TPD52L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPD52L3→partner) and Y-score (partner→TPD52L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM161B →	+0.418	+2.716	.007	.003	3	3
UCEC	PTGES →	-1.019	-3.574	.001	.002	3	3
UCEC	WDHD1 →	+0.559	+2.021	.007	.005	3	3
COAD	C18orf25 →	+0.595	+3.229	<.001	.009	3	3
COAD	ZNF367 →	+0.639	+3.223	.005	.009	3	3
UCEC	TMEM269 →	+0.256	+3.613	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,135 associations by consensus.

TMEM161B by TPD52L3 expression — UCEC

Explore this box plot interactively →