TPD52L3

Across TCGA patient cohorts, TPD52L3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPD52L3-associated genes across cancer lineages are PDCD4, mTOR_pS2448, and N-Cadherin. Each is linked with TPD52L3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TPD52L3-to-partner and partner-to-TPD52L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by TPD52L3-low versus TPD52L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPD52L3→partner) and Y-score (partner→TPD52L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.544	-1.700	.006	.044	3	3
UCEC	mTOR_pS2448 →	-0.135	-2.302	.033	.034	3	2
UCEC	N-Cadherin →	+0.252	+1.700	.005	.044	2	3
UCEC	p38-MAPK →	-0.176	-2.301	.011	.034	3	2
UCEC	PCNA →	+0.212	+2.999	.021	.035	3	2
COAD	Shc_pY317 →	-0.250	-2.991	.004	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PDCD4 by TPD52L3 expression — UCEC

Explore this box plot interactively →