TPD52L2

Across TCGA patient cohorts, TPD52L2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPD52L2-associated genes across cancer lineages are Myosin-IIa_pS1943, FoxM1, and INPP4B. Each is linked with TPD52L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPD52L2-to-partner and partner-to-TPD52L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by TPD52L2-low versus TPD52L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPD52L2→partner) and Y-score (partner→TPD52L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.187	+2.235	.033	.006	3	2
UCEC	FoxM1 →	+0.238	+2.222	.030	.011	3	1
UCEC	INPP4B →	-0.294	-1.687	.032	.044	3	1
UCEC	JNK_pT183_Y185 →	-0.184	-2.209	.009	.011	3	1
UCEC	JNK2 →	+0.288	+2.906	<.001	.001	3	1
UCEC	Ku80 →	+0.294	+2.920	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Myosin-IIa_pS1943 by TPD52L2 expression — UCEC

Explore this box plot interactively →