TPD52L2

Across TCGA cell cohorts, TPD52L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,141 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TPD52L2-associated GO terms across cancer lineages are Protein linear deubiquitination, Mitotic centrosome separation, and IRE1-mediated unfolded protein response. Each is linked with TPD52L2 in more than 13 cancer types. Because this analysis shows association rather than direction, both TPD52L2-to-partner and partner-to-TPD52L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein linear deubiquitination grouped by TPD52L2-low versus TPD52L2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TPD52L2→partner) and Y-score (partner→TPD52L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein linear deubiquitination →	+0.851	+0.536	<.001	.005	2	14
SKIN	Mitotic centrosome separation →	+0.145	+0.849	<.001	<.001	3	12
STOMACH	IRE1-mediated unfolded protein response →	+0.224	+0.960	<.001	<.001	3	12
BONE	Vesicle-mediated transport to the plasma membrane →	+0.073	+0.895	.001	<.001	3	12
URINARY_TRACT	Negative regulation of t-circle formation →	+0.112	+0.535	.007	.004	2	12
BONE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.163	+0.637	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,141 associations by consensus.

Protein linear deubiquitination by TPD52L2 expression — BONE

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