TPD52L1

Across TCGA patient cohorts, TPD52L1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPD52L1-associated genes across cancer lineages are ASNS, ATM, and EGFR_pY1068. Each is linked with TPD52L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPD52L1-to-partner and partner-to-TPD52L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TPD52L1-low versus TPD52L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPD52L1→partner) and Y-score (partner→TPD52L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.518	+2.459	.002	.020	3	2
UCEC	ATM →	-0.805	-3.169	<.001	.019	3	2
UCEC	EGFR_pY1068 →	-0.273	-3.000	.024	.036	3	1
UCEC	P-Cadherin →	-0.182	-2.311	.009	.034	3	1
UCEC	PCNA →	+0.325	+2.999	.001	.035	3	1
UCEC	PRAS40_pT246 →	+0.199	+3.000	.016	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ASNS by TPD52L1 expression — UCEC

Explore this box plot interactively →