TPD52

Across TCGA patient cohorts, TPD52 protein abundance is significantly associated with the RNA expression of many other genes, with 15,060 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TPD52-associated genes across cancer lineages are OLFML2B, ARHGAP23, and MEIS3. Each is linked with TPD52 in more than 6 cancer types. Because this analysis shows association rather than direction, both TPD52-to-partner and partner-to-TPD52 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPD52 versus OLFML2B in BRCA, with a Pearson correlation of -0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPD52→partner) and Y-score (partner→TPD52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OLFML2B →	-1.131	-0.901	<.001	<.001	3	7
BRCA	ARHGAP23 →	-0.842	-0.647	<.001	.001	3	7
UCEC	MEIS3 →	-0.899	-0.357	.002	.009	3	6
BRCA	PCOLCE →	-0.900	-0.610	<.001	<.001	3	6
UCEC	TSHZ3 →	-1.086	-0.524	<.001	<.001	3	6
BRCA	COL5A1 →	-1.536	-0.790	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,060 associations by consensus.

TPD52 vs OLFML2B — BRCA

Explore this scatter interactively →