TPD52

Across TCGA patient cohorts, TPD52 mutation is significantly associated with the RNA expression of many other genes, with 743 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPD52-associated genes across cancer lineages are RNU6-752P, RNU6-864P, and RNA5SP161. Each is linked with TPD52 in more than 2 cancer types. Because this analysis shows association rather than direction, both TPD52-to-partner and partner-to-TPD52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-752P grouped by TPD52-low versus TPD52-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPD52→partner) and Y-score (partner→TPD52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-752P →	+0.297	+5.212	<.001	.002	3	3
LUAD	RNU6-864P →	+0.468	+7.930	<.001	.008	3	2
UCEC	RNA5SP161 →	+0.878	+2.306	<.001	.001	3	2
UCEC	MIR615 →	+0.340	+2.580	<.001	.003	3	2
UCEC	RNU6-718P →	+0.165	+3.761	<.001	.001	3	2
UCEC	NDUFB10P1 →	+0.217	+2.229	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 743 associations by consensus.

RNU6-752P by TPD52 expression — SKCM

Explore this box plot interactively →