TPD52

Across TCGA patient cohorts, TPD52 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPD52-associated genes across cancer lineages are ACC_pS79, JNK2, and MEK1. Each is linked with TPD52 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPD52-to-partner and partner-to-TPD52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by TPD52-low versus TPD52-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPD52→partner) and Y-score (partner→TPD52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.383	+3.009	.014	.019	3	1
UCEC	JNK2 →	+0.185	+2.834	.038	.034	3	1
UCEC	MEK1 →	+0.372	+2.000	.024	.032	3	1
UCEC	Annexin-1 →	+0.634	+3.019	.007	.019	3	1
UCEC	Tuberin_pT1462 →	+0.228	+2.469	.028	.010	3	1
UCEC	Caspase-8 →	-0.262	-3.143	.020	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ACC_pS79 by TPD52 expression — UCEC

Explore this box plot interactively →