TPCN2

Across TCGA pan-cancer cohorts, TPCN2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TPCN2 data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher TPCN2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TPCN2 expression acts as an unfavorable survival marker.

UCS, KIRP, and BLCA are the cancer types where TPCN2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	All	0.068	0.524	<.001	48	view →
KIRP	DFS	Median	All	0.088	0.920	<.001	48	view →
BLCA	OS	Median	All	0.052	0.688	<.001	36	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TPCN2–UCS (DFS)

Open the UCS breakdown →