TPCN2

Across TCGA cell cohorts, TPCN2 mutation is significantly associated with the mutation status of many other genes, with 4,202 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPCN2-associated genes across cancer lineages are BPTF, ZNF865, and CCDC27. Each is linked with TPCN2 in more than 4 cancer types. Because this analysis shows association rather than direction, both TPCN2-to-partner and partner-to-TPCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPTF grouped by TPCN2-low versus TPCN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPCN2→partner) and Y-score (partner→TPCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPTF →	+2.056	+3.450	<.001	<.001	1	5
LARGE_INTESTINE	ZNF865 →	+2.149	+3.000	<.001	<.001	1	5
BLOOD_Leukemia	CCDC27 →	+3.430	+3.313	.005	.005	1	4
BLOOD_Leukemia	TRAPPC9 →	+2.707	+3.478	<.001	<.001	1	4
BLOOD_Leukemia	CELSR1 →	+2.038	+3.415	.001	.001	1	4
BLOOD_Leukemia	PKD1 →	+1.897	+4.195	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,202 associations by consensus.

BPTF by TPCN2 expression — LARGE_INTESTINE

Explore this box plot interactively →