Across TCGA pan-cancer cohorts, TPCN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TPCN1 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TPCN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TPCN1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where TPCN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.601	0.933	.002	13	view →
PDAC	DFS	Quartile	III,IV	0.476	0.939	.014	9	view →
LUAD	OS	Median	All	0.973	0.910	.023	6	view →
UCEC	OS	Median	III,IV	0.285	0.847	.049	4	view →
HNSC	OS	Quartile	All	0.807	0.574	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TPCN1 tumor-vs-normal RNA expression · all TPCN1 data types