Across TCGA patient cohorts, TPCN1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,536 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TPCN1-associated genes across cancer lineages are SDC4, PNN, and MVP. Each is linked with TPCN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TPCN1-to-partner and partner-to-TPCN1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPCN1→partner) and Y-score (partner→TPCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SDC4 →	+1.002	+0.471	<.001	.001	3	5
UCEC	PNN →	-0.383	-0.285	.002	.003	2	5
BRCA	MVP →	+0.763	+0.278	<.001	.001	3	4
BRCA	SDSL →	+0.673	+0.258	.006	.009	2	5
LSCC	ZBTB26 →	-0.558	-0.183	<.001	.004	3	4
LSCC	ZNF184 →	-0.585	-0.298	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,536 associations by consensus.

Exploration

TPCN1 survival (RNA) · tumor vs normal (RNA) · all TPCN1 data types