Across TCGA patient cohorts, TPCN1 mutation is significantly associated with the RNA expression of many other genes, with 3,123 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPCN1-associated genes across cancer lineages are TLE6, APTX, and TRAV15. Each is linked with TPCN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TPCN1-to-partner and partner-to-TPCN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPCN1→partner) and Y-score (partner→TPCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TLE6 →	+0.519	+1.699	.002	<.001	3	3
UCEC	APTX →	+0.276	+2.828	<.001	<.001	3	3
COAD	TRAV15 →	+0.091	+3.053	<.001	.007	3	3
UCEC	ZNHIT3 →	+0.330	+1.895	.001	<.001	3	2
UCEC	TAF9 →	+0.621	+1.678	<.001	<.001	3	2
UCEC	CCL4 →	+0.931	+2.271	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,123 associations by consensus.

Exploration

TPCN1 survival (RNA) · tumor vs normal (RNA) · all TPCN1 data types