Across TCGA cell cohorts, TPCN1 mutation is significantly associated with the RNA expression of many other genes, with 200 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TPCN1-associated genes across cancer lineages are OR6B1, DDX59, and CATSPERB. Each is linked with TPCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TPCN1-to-partner and partner-to-TPCN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPCN1→partner) and Y-score (partner→TPCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR6B1 →	+0.020	+5.285	<.001	.003	3	2
LARGE_INTESTINE	DDX59 →	+0.560	+3.389	<.001	.001	3	2
LARGE_INTESTINE	CATSPERB →	+0.799	+3.321	<.001	.003	3	2
LARGE_INTESTINE	GGACT →	+0.637	+2.628	.004	.002	3	2
LARGE_INTESTINE	TIPRL →	+0.341	+3.169	.008	.006	3	2
LUNG_NSCLC_LUAD	XAGE5 →	+0.796	+3.604	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 200 associations by consensus.

Exploration

TPCN1 survival (RNA) · tumor vs normal (RNA) · all TPCN1 data types