TPBGL

Across TCGA patient cohorts, TPBGL protein abundance is significantly associated with the RNA expression of many other genes, with 120 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TPBGL-associated genes across cancer lineages are CRYAB, PRKAB1, and CR2. Each is linked with TPBGL in more than 1 cancer types. Because this analysis shows association rather than direction, both TPBGL-to-partner and partner-to-TPBGL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TPBGL versus CRYAB in GBM, with a Pearson correlation of -0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPBGL→partner) and Y-score (partner→TPBGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CRYAB →	-1.245	-0.708	.005	<.001	3	1
GBM	PRKAB1 →	-0.358	-0.786	<.001	.004	3	1
GBM	CR2 →	+0.179	+0.849	.005	<.001	3	1
GBM	PPP4R4 →	+1.000	+0.663	.003	.001	3	1
GBM	CHCHD5 →	-0.617	-0.954	<.001	.003	3	1
GBM	CSNK1D →	-0.297	-0.700	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

TPBGL vs CRYAB — GBM

Explore this scatter interactively →