TP73

Across TCGA patient cohorts, TP73 mutation is significantly associated with the RNA expression of many other genes, with 2,096 significant associations in total. CESC shows the largest number of these associations.

The most reproducible TP73-associated genes across cancer lineages are NSD2, C1orf174, and PBK. Each is linked with TP73 in more than 3 cancer types. Because this analysis shows association rather than direction, both TP73-to-partner and partner-to-TP73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NSD2 grouped by TP73-low versus TP73-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP73→partner) and Y-score (partner→TP73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NSD2 →	+0.472	+1.711	<.001	.001	3	4
UCEC	C1orf174 →	+0.300	+2.212	.004	.001	3	4
COAD	PBK →	+0.979	+3.740	<.001	<.001	3	4
CESC	COX10 →	+0.456	+3.351	.003	.005	3	3
UCEC	PNPLA3 →	+0.444	+1.928	.007	.008	3	3
UCEC	ERI1 →	+0.522	+1.700	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,096 associations by consensus.

NSD2 by TP73 expression — UCEC

Explore this box plot interactively →