TP73

Across TCGA cell cohorts, TP73 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,686 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TP73-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Negative regulation of cell cycle process, and Positive regulation of lung ciliated cell differentiation. Each is linked with TP73 in more than 11 cancer types. Because this analysis shows association rather than direction, both TP73-to-partner and partner-to-TP73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by TP73-low versus TP73-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TP73→partner) and Y-score (partner→TP73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Epigenetic regulation of gene expression →	+0.060	+1.264	<.001	<.001	3	12
PANCREAS	Negative regulation of cell cycle process →	+0.068	+0.976	<.001	.001	3	11
BLOOD_Lymphoma	Positive regulation of lung ciliated cell differentiation →	+1.290	+2.623	<.001	<.001	3	11
OESOPHAGUS	Negative regulation of mRNA catabolic process →	+0.081	+1.832	.007	<.001	3	10
BONE	Double-strand break repair →	+0.087	+1.271	.003	.002	3	10
BONE	DNA recombination →	+0.094	+1.506	.005	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,686 associations by consensus.

Epigenetic regulation of gene expression by TP73 expression — SOFT_TISSUE

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