TP73

Across TCGA cell cohorts, TP73 mutation is significantly associated with the RNA expression of many other genes, with 513 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TP73-associated genes across cancer lineages are SPP2, MRAP, and NPVF. Each is linked with TP73 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP73-to-partner and partner-to-TP73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPP2 grouped by TP73-low versus TP73-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP73→partner) and Y-score (partner→TP73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPP2 →	+0.103	+4.060	<.001	.003	3	2
BLOOD_Lymphoma	MRAP →	+0.018	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	NPVF →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR1A2 →	+0.017	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	KRT28 →	+0.006	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 513 associations by consensus.

SPP2 by TP73 expression — BLOOD_Leukemia

Explore this box plot interactively →