Across TCGA pan-cancer cohorts, TP73-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated TP73-AS1 data layer compared with 2 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher TP73-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TP73-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

LGG, LUSC, and ACC are the cancer types where TP73-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.655	0.814	<.001	51	view →
LUSC	DFS	Median	III,IV	0.157	0.834	<.001	50	view →
ACC	DFS	Median	All	0.433	0.719	.003	41	view →
BRCA	OS	Tertile	III,IV	0.960	0.847	.002	36	view →
HNSC	DFS	Quartile	III,IV	0.806	0.584	.001	30	view →
KIRP	DFS	Median	All	1.000	0.788	.001	26	view →
LUAD	DFS	Median	All	0.836	0.696	.002	22	view →
SKCM	OS	Tertile	II,III,IV	0.668	0.799	.007	19	view →
CESC	DFS	Tertile	All	0.638	0.831	.001	18	view →
ESCA	OS	Quartile	II,III,IV	0.684	0.357	.013	18	view →
THCA	DFS	Median	IV	0.535	0.810	.015	13	view →
DLBC	DFS	Median	All	0.599	0.921	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

Exploration

Same gene, other analysis: TP73-AS1 tumor-vs-normal RNA expression · all TP73-AS1 data types