Across TCGA patient cohorts, TP53TG3D mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53TG3D-associated genes across cancer lineages are FOXO3a_pS318_S321, Ku80, and MEK1. Each is linked with TP53TG3D in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53TG3D-to-partner and partner-to-TP53TG3D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53TG3D→partner) and Y-score (partner→TP53TG3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.184	-3.312	.001	.010	3	1
UCEC	Ku80 →	+0.278	+3.013	.011	.018	3	1
UCEC	MEK1 →	+0.390	+2.584	.022	.011	3	1
UCEC	mTOR_pS2448 →	-0.167	-2.584	.016	.011	3	1
UCEC	p70-S6K_pT389 →	-0.220	-2.312	.013	.034	3	1
UCEC	PKC-b-II_pS660 →	-0.329	-2.584	.010	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

TP53TG3D survival (RNA) · tumor vs normal (RNA) · all TP53TG3D data types