TP53INP2

Across TCGA pan-cancer cohorts, TP53INP2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TP53INP2 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TP53INP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TP53INP2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where TP53INP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.649	0.903	.002	52	view →
PDAC	DFS	Tertile	All	0.978	0.605	.002	45	view →
LUAD	OS	Median	All	0.872	1.000	.007	21	view →
LSCC	DFS	Quartile	All	1.000	0.575	.002	21	view →
COAD	DFS	Median	All	1.000	0.894	.035	18	view →
CCRCC	DFS	Median	III,IV	0.919	0.556	.017	6	view →
GBM	DFS	Quartile	All	0.435	0.815	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TP53INP2–HNSC (DFS)

Open the HNSC breakdown →