TP53INP2

Across TCGA pan-cancer cohorts, TP53INP2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TP53INP2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TP53INP2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TP53INP2 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and CCRCC are the cancer types where TP53INP2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TP53INP2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.237	<.001	11	view →
LUAD	Female	All	−0.971	<.001	8	view →
CCRCC	Male	All	+0.767	<.001	8	view →
LSCC	All	All	−0.273	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TP53INP2–COAD

Open the COAD breakdown →