TP53INP2

Across TCGA patient cohorts, TP53INP2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53INP2-associated genes across cancer lineages are FOXO3a_pS318_S321, Notch1, and ATM. Each is linked with TP53INP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53INP2-to-partner and partner-to-TP53INP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TP53INP2-low versus TP53INP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53INP2→partner) and Y-score (partner→TP53INP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.128	-2.990	.049	.036	3	1
UCEC	Notch1 →	+0.158	+2.817	.032	.036	3	1
UCEC	ATM →	-0.673	-3.321	.004	.010	3	1
UCEC	PDCD4 →	-0.890	-3.321	<.001	.010	2	1
UCEC	TFRC →	+0.986	+3.321	<.001	.010	2	1
UCEC	TIGAR →	+0.177	+3.348	.026	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOXO3a_pS318_S321 by TP53INP2 expression — UCEC

Explore this box plot interactively →