TP53INP1

Across TCGA patient cohorts, TP53INP1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53INP1-associated genes across cancer lineages are A-Raf_pS299, FOXO3a, and JNK2. Each is linked with TP53INP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53INP1-to-partner and partner-to-TP53INP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TP53INP1-low versus TP53INP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53INP1→partner) and Y-score (partner→TP53INP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.116	-3.169	.026	.019	3	1
UCEC	FOXO3a →	-0.087	-2.292	.049	.034	3	1
UCEC	JNK2 →	+0.248	+3.469	.004	.002	3	1
UCEC	Ku80 →	+0.326	+1.887	.001	.029	3	1
UCEC	Notch1 →	+0.141	+2.115	.021	.019	3	1
UCEC	Tuberin →	+0.420	+2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

A-Raf_pS299 by TP53INP1 expression — UCEC

Explore this box plot interactively →