TP53I3

Across TCGA pan-cancer cohorts, TP53I3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TP53I3 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TP53I3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TP53I3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where TP53I3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.913	0.569	.013	25	view →
LSCC	DFS	Quartile	All	0.858	1.000	.008	12	view →
LUAD	DFS	Tertile	All	0.411	0.747	.002	12	view →
HNSC	OS	Median	IV	0.629	0.837	.032	3	view →
GBM	OS	Quartile	All	0.744	0.923	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TP53I3–CCRCC (DFS)

Open the CCRCC breakdown →