TP53I11

Across TCGA pan-cancer cohorts, TP53I11 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TP53I11 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TP53I11 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TP53I11 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where TP53I11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.750	0.979	.007	18	view →
LSCC	OS	Median	All	0.919	1.000	.008	10	view →
LUAD	OS	Median	All	0.622	0.852	.043	4	view →
PDAC	OS	Tertile	IV	0.319	0.956	.038	3	view →
CCRCC	DFS	Tertile	III,IV	1.000	0.481	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TP53I11–UCEC (DFS)

Open the UCEC breakdown →