TP53I11

Across TCGA patient cohorts, TP53I11 mutation is significantly associated with the RNA expression of many other genes, with 435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53I11-associated genes across cancer lineages are HMGB1P42, MIR8053, and IGHV3OR16-6. Each is linked with TP53I11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53I11-to-partner and partner-to-TP53I11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P42 grouped by TP53I11-low versus TP53I11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53I11→partner) and Y-score (partner→TP53I11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HMGB1P42 →	+0.082	+6.199	<.001	.001	3	2
SKCM	MIR8053 →	+0.493	+6.328	<.001	.001	3	2
UCEC	IGHV3OR16-6 →	+0.508	+3.102	.007	.001	3	1
UCEC	IGKV2OR2-7D →	+0.114	+3.356	<.001	.005	3	1
UCEC	IGHV3OR16-13 →	+0.613	+3.481	.009	<.001	3	1
UCEC	SRXN1 →	+0.818	+3.375	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 435 associations by consensus.

HMGB1P42 by TP53I11 expression — SKCM

Explore this box plot interactively →