TP53I11

Across TCGA patient cohorts, TP53I11 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53I11-associated genes across cancer lineages are p62 Lck ligand, PDK1_pS241, and Shc_pY317. Each is linked with TP53I11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53I11-to-partner and partner-to-TP53I11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by TP53I11-low versus TP53I11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53I11→partner) and Y-score (partner→TP53I11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.502	+3.321	.003	.010	3	1
UCEC	PDK1_pS241 →	+0.201	+2.183	.024	.035	3	1
UCEC	Shc_pY317 →	-0.178	-3.169	.025	.019	3	1
UCEC	4E-BP1 →	+0.415	+2.837	.003	.035	3	1
UCEC	C-Raf →	+0.237	+3.169	.001	.019	3	1
UCEC	Di-Ras3 →	-0.208	-3.000	.007	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

p62 Lck ligand by TP53I11 expression — UCEC

Explore this box plot interactively →